Diagnosis, pathogenesis and treatment of myositis: recent advances

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Abstract:

Dermatomyositis (DM), polymyositis (PM), necrotizing myopathy (NM) and inclusion body myositis (IBM) are four distinct subtypes of idiopathic inflammatory myopathies - in short myositis. Recent studies have shed some light on the unique pathogenesis of each entity. Some of the clinical features are distinct, but muscle biopsy is indispensable for making a reliable diagnosis. The use of magnetic resonance imaging of skeletal muscles and detection of myositis-specific autoantibodies have become useful additions to our diagnostic repertoire. Only few controlled trials are available to substantiate current treatment approaches for myositis and hopes are high that novel modalities will become available within the next few years. In this review we provide an up-to-date overview of the pathogenesis and diagnostic approach of myositis. We aim to present a guide towards therapeutic and general management.

SEEK ID: https://ldh.drfz.imise.uni-leipzig.de/publications/39

DOI: 10.1111/cei.12194

Projects: German National Database of the Regional Cooperative Arthritis Centres (...

Publication type: Journal

Journal: Clin Exp Immunol

Citation: Clin Exp Immunol 175(3):349-58

Date Published: 2014

URL: https://www.ncbi.nlm.nih.gov/pubmed/23981102

Registered Mode: imported from a bibtex file

Authors: P. O. Carstens, J. Schmidt

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Adrian Richter

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Carstens, P.-O., & Schmidt, J. (2014). Diagnosis, pathogenesis and treatment of myositis: recent advances. In Clinical and Experimental Immunology (Vol. 175, Issue 3, pp. 349–358). Oxford University Press (OUP). https://doi.org/10.1111/cei.12194

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Created: 15th Jul 2025 at 08:48

Diagnosis, pathogenesis and treatment of myositis: recent advances

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