[Influence of therapy on risk of cancer in rheumatoid arthritis. Pathophysiological principles]

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Abstract:

The increased incidence of certain tumor entities in chronic inflammation and infections as well as the increased tumor risk under immunosuppression, illustrate the multiple and complex influences of the immune system on tumor pathogenesis. It is therefore conceivable that immunomodulatory therapy for rheumatoid arthritis (RA) could also influence the risk of malignancies, apart from treating the underlying disease. Basic scientific research studies have identified various signal transduction pathways that are relevant for tumorigenesis and tumor defense mechanisms. This review presents the current knowledge on the effects of the immune system on the occurrence of cancer and tries, where possible, to relate it to specific treatment options.

SEEK ID: https://ldh.drfz.imise.uni-leipzig.de/publications/176

DOI: 10.1007/s00393-015-0033-7

Projects: RABBIT (Rheumatoid Arthritis - Observation of Biologic Therapies)

Publication type: Journal

Journal: Z Rheumatol

Citation: Z Rheumatol 75(1):13-21

Date Published: 2016

URL: https://www.ncbi.nlm.nih.gov/pubmed/26786169

Registered Mode: imported from a bibtex file

Authors: M. J. Waldner, A. Strangfeld, M. Aringer

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Adrian Richter

Citation

Waldner, M. J., Strangfeld, A., & Aringer, M. (2016). Einfluss der Therapie auf das Krebsrisiko bei rheumatoider Arthritis. In Zeitschrift für Rheumatologie (Vol. 75, Issue 1, pp. 13–21). Springer Science and Business Media LLC. https://doi.org/10.1007/s00393-015-0033-7

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Created: 15th Jul 2025 at 09:47

[Influence of therapy on risk of cancer in rheumatoid arthritis. Pathophysiological principles]

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